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Last Updated: Jul 19, 2026

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Nursing ACNS Exam Syllabus Topics:

SectionWeightObjectives
Topic 1: Clinical Expertise in Adult Health40-50%- Diagnostics and Laboratory Interpretation
- Acute and Chronic Disease Management
- Therapeutic Interventions and Treatments
- Pharmacology for Adult Populations
- Health Assessment and Promotion
- Pathophysiology and Clinical Management
Topic 2: Education and Research10-15%- Data Analysis and Outcome Measurement
- Clinical Scholarship and Publication
- Research Utilization and Evidence Appraisal
- Patient and Staff Education
Topic 3: Leadership and Consultation15-20%- Change Management and Innovation
- Healthcare Leadership Principles
- Quality Improvement and Patient Safety
- Consultation and Collaboration Skills
- Interprofessional Team Collaboration
Topic 4: Foundations of Advanced Practice8-12%- Advanced Practice Role Development
- Evidence-Based Practice Principles
- Theoretical Foundations of Nursing
- Professional Ethics and Legal Issues
- Healthcare Policy and Advocacy
Topic 5: Systems and Outcomes10-15%- Regulatory Compliance and Standards
- Risk Management and Quality Assurance
- Healthcare Delivery Systems
- Healthcare Informatics and Technology
- Resource Management and Cost-Effectiveness

Nursing ANCC Adult Health Clinical Nurse Specialist Certification (ACNS) Sample Questions:

1. Screening for cancer in the geriatric population includes all of the following recommendations except:

A) skin cancer
B) cervical cancer
C) prostate cancer
D) colon cancer


2. The U.S. Food and Drug Administration (FDA) and the Department of Health and Human Services (DHHS) have regulations governing research activities on human subjects. The CNS understands that the principle investigator is responsible for:

A) Going before the Institutional Review Board to present the study and gain approval to proceed with subject recruitment.
B) Securing a signed consent form allowing the research.
C) All of the above.
D) Reporting to the Institutional Review Board if a subject is injured during the course of the study.


3. A patient who demonstrates a high-pitched harsh sound on inhalation is described as having which of the following?

A) Sibilant breath sounds.
B) Vesicular breath sounds.
C) Bronchial breath sounds.
D) Stridor breath sounds.


4. What is Not a step in Values Clarification?

A) Choosing.
B) Utility.
C) Acting.
D) Prizing.


5. Hematocrit is also known as what?

A) MVC.(mean value of cells)
B) PVC. (premature ventricular contraction)
C) PCV. (packed cell volume)
D) MCV. (mean cell volume)


Solutions:

Question # 1
Answer: B
Question # 2
Answer: C
Question # 3
Answer: D
Question # 4
Answer: B
Question # 5
Answer: C

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