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Last Updated: Jul 30, 2026

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USMLE Step 1 is a one-day (8 hours) examination. It includes 322 multiple-choice questions divided into 7 blocks of 46 items (60 minutes are given for completion of each block).

USMLE Step 2 is open to all medical students and graduates who have successfully passed the USMLE Step 1. The Step 2 exam assesses the candidates' medical knowledge, skills, and understanding of clinical science essential for patient treatment and care, health promotion and disease prevention.

USMLE Step 2 is a one-day (8 hours) exam. Similar to the Step 1, the test items are divided into blocks, and test item formats vary within each block, with the total number of exam questions equaling to 355.

Reference: http://www.usmle.org/step-1/#question-formats

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USMLE USMLE Exam Syllabus Topics:

SectionObjectives
Topic 1: Cardiovascular System- Cardiac and Vascular Disorders
  • 1. Heart Disease
  • 2. Vascular Pathology
Topic 2: Multisystem Processes and Disorders- Systemic Conditions
  • 1. Neoplasia
  • 2. Infectious Diseases
  • 3. Nutrition
Topic 3: Renal and Urinary System- Kidney and Urinary Disorders
  • 1. Renal Physiology
  • 2. Renal Pathology
Topic 4: Endocrine System- Hormonal Regulation and Disease
  • 1. Pituitary Disorders
  • 2. Thyroid Disorders
  • 3. Adrenal Disorders
Topic 5: Musculoskeletal System- Bones, Joints, and Muscles
  • 1. Rheumatologic Diseases
  • 2. Orthopedic Disorders
Topic 6: Skin and Related Connective Tissue- Dermatologic Conditions
  • 1. Inflammatory Skin Disorders
  • 2. Skin Neoplasms
Topic 7: General Principles- Foundational Medical Sciences
  • 1. Immunology
  • 2. Genetics
  • 3. Microbiology
  • 4. Physiology
  • 5. Pathology
  • 6. Pharmacology
  • 7. Behavioral Sciences
  • 8. Biochemistry
Topic 8: Reproductive System- Male and Female Reproductive Health
  • 1. Reproductive Disorders
  • 2. Reproductive Physiology
Topic 9: Respiratory System- Pulmonary Medicine
  • 1. Airway Disorders
  • 2. Lung Diseases
Topic 10: Hematopoietic and Lymphoreticular Systems- Blood and Immune Disorders
  • 1. Coagulation Disorders
  • 2. Leukemias and Lymphomas
  • 3. Anemias
Topic 11: Gastrointestinal System- Digestive System Disorders
  • 1. Liver Disease
  • 2. Gastrointestinal Pathology
Topic 12: Central and Peripheral Nervous Systems- Neurologic Disorders
  • 1. Neuroanatomy
  • 2. Neurologic Diseases
  • 3. Neuropathology
Topic 13: Human Development- Growth and Development
  • 1. Embryology
  • 2. Developmental Abnormalities

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